2-Hydroxybenzyl alcohol–phenanthroline (1/1)
نویسندگان
چکیده
Crystals of the title compound, C(12)H(8)N(2)·C(7)H(8)O(2), were obtained during cocrystallization experiments of a compound with two hydrogen-bond donors (2-hydroxy-benzyl alcohol) with another compound containing two hydrogen-bond acceptors (phenanthroline). Unexpectedly, the two mol-ecules do not form dimers with two O-H⋯N hydrogen bonds connecting the two mol-ecules. However, one of the hydr-oxy groups forms a bifurcated hydrogen bond to both phenanthroline N atoms, whereas the other hydr-oxy group forms an O-H⋯O hydrogen bond to a symmetry-equivalent 2-hydroxy-benzyl alcohol mol-ecule. In addition, the crystal packing is stabilized by π-π inter-actions between the two phenanthroline ring systems, with a centroid-centroid distance of 3.570 Å.
منابع مشابه
The role of zinc in alcohol dehydrogenase. IV. The kinetics of the instantaneous inhibition of horse liver alcohol dehydrogenase by 1,10-phenanthroline.
The alcohol dehydrogenase crystallized from horse liver contains 2 atoms of zinc per molecule and the activity of this enzyme is inhibited by metal-binding agents (1, 2). The inhibition of liver alcohol dehydrogenase by one of these agents, 1, IO-phenanthroline, differs from that which is observed when the alcohol dehydrogenase isolated from yeast is exposed to 1, lo-phenanthroline (3). The liv...
متن کاملThe Role of Zinc in Alcohol Dehydrogenase IV. THE KIh’ETICS OF THE INSTANTANEOUS INHIBITION OF HORSE LIVER ALCOHOL DEHYDROGENASE BY 1 , lo-PHENANTHROLINE*
The alcohol dehydrogenase crystallized from horse liver contains 2 atoms of zinc per molecule and the activity of this enzyme is inhibited by metal-binding agents (1, 2). The inhibition of liver alcohol dehydrogenase by one of these agents, 1, IO-phenanthroline, differs from that which is observed when the alcohol dehydrogenase isolated from yeast is exposed to 1, lo-phenanthroline (3). The liv...
متن کاملState and accessibility of zinic in yeast alcohol dehydrogenase.
1. Yeast alcohol dehydrogenase (EC 1.1.1.1) is inhibited in the presence of 1,10-phenanthroline. 2. A conformational change in the enzyme's structure is induced by 1,10-phenanthroline, and is abolished in the presence of NADH. 1,10-Phenanthroline binds to the enzyme competitively with respect to NADH, with a stoicheiometry of 2 mol of 1,10-phenanthroline/144000g of enzyme. 3. 1,10-Phenanthrolin...
متن کاملComplex formation of 1,10-phenanthroline with zinc ions and the zinc of alcohol dehydrogenase of horse liver.
1, IO-Phenanthroline interacts with certain zinc metalloenzymes to form enzymatically inactive protein-zinc-phenanthroline complexes exhibiting ultraviolet absorption maxima analogous to those observed for zinc ions and phenanthroline in aqueous systems (1). Such spectral changes offer a means of studying directly the chemical mechanism of the enzymatic inhibition resulting from such interactio...
متن کاملSerum iron determination.
N IRON REAGENT, 4 ,7-diphenyl-1 , lO-phenanthroline, which has a more desirable sensitivity than other known iron reagents, has been introduced by Case (1), has been used by Smith et at. (2) in the estimation of iron in water, and in serum by Peterson (3) who reported the molar absorbency index of the iron complex of this new reagent as almost three times that of a-a’-dipyridyl or o-phenanthrol...
متن کامل